hrp0097p1-492 | GH and IGFs | ESPE2023

GH stimulation testing: is it time to change the paradigm?

Smuel Keren , Lazar Liora , Yackobovitch-Gavan Michal , Tirosh Liron , Phillip Moshe , Oron Tal , Sarah Flanagan , Jayne Houghton

Background: The efficacy of growth hormone (GH) treatment in short, healthy children diagnosed with growth hormone deficiency (GHD) or those meeting the criteria of idiopathic short stature (ISS) suggest that an overlap exists between these two conditions. Although flawed and inconsistent, growth hormone stimulation tests (GHST) are the key diagnostic tool differentiating between GHD and ISS affecting clinical decisions such as treatment eligibility and dose.<...